Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study. With contributions from a cadre of international experts, this volume examines: The biology of DHEA relevant to health in humans Areas of potential clinical importance concerning low levels of DHEA related to age or physiological change Prevention as well as treatment of various human disease states by changing DHEA levels The use of DHEA levels in predicting the risk of disease The role of DHEA in diabetes, fitness, infectious disease, cancer, AIDS, bone health, cardiovascular diseases, autism, and mental health Animal models and their relation to studies done on humans The effects of loss of adrenal gland function, the subsequent reduction in DHEA production, and its replacement as therapy Adverse effects in DHEA-supplemented women Mechanisms of action of DHEA in prostate and ovarian health, vascular modification, stress, memory, aggression, and Alzheimer's disease Covering a wide range of topics, the book is compiled from contributions of experts who have each studied some aspect of DHEA and human or animal health or disease. Every chapter is self-contained, allowing for focused study on individual topics. Edited by one of the leading experts in the field of nutrition, the book presents a compelling view of the state of the science in DHEA.

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including: Gut motility and gastrointestinal diseases Anesthesia and surgery Bone health Breast cancer Cardiovascular diseases Diabetes Age-related macular degeneration and uveitis Melanoma, solar skin damage, and collagen synthesis The prevention of DNA damage Mental disorders, sleep, and issues related to jet lag and shift work The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities, making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters. Highlights Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health Tocopherol interference with tocotrienol functions All new chapters and many new contributors Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies. Dr. Tan discusses the benefits of tocotrienol in a YouTube video.

Reviews in Food and Nutrition Toxicity, Volume 4 includes the most recent reviews of current issues involved in the toxicity of food and nutrients. With contributors from the fields of medicine, public health, and environmental science, the continuation of this series distills a broad range of research on food safety and food technology. Volume Four discusses: The extent to which postnatal metal exposure through breastfeeding can impair an infant's health Selenium bioavailability and metabolism, effects of selenium exposure, and mechanisms of selenium toxicity The fate of toxic and nontoxic arsenic compounds in the human body upon ingestion The biological role of sulfur, sulfur metabolism, deficiencies, and toxicity The effects on fluoride on teeth, bones, kidneys, arteries, hormones, the brain, and the reproductive system Food-borne disease outbreaks, microbial quality and risk assessment of food-borne microorganisms in ready to eat foods Effect of T-2 toxin on DNA and chromosomes, circulatory system, skin, reproductive system, liver and spleen, gastrointestinal tract, brain and neurotransmitters, and more Investigation of the interference of AFB1 with molecular components of cell cycle checkpoints Analyzes cycad consumption and its effects on the neurological systems and its manifestations; describes bio-chemical changes and morphological or pathological outcomes through time in detail Lectins in the human diet, toxicity and biological effects, immunomodulatory effects, modulation of immune function by dietary lectins in disease This is a valuable resource for anyone involved in the food industry or academics researching food science and food technology.

Melatonin is a powerful hormone and antioxidant with numerous effects on the metabolism and the health of humans. Available as a dietary supplement in the United States since 1993, it is one of the most popular over-the-counter alternative remedies available. Comprising contributions from researchers who have studied the role of melatonin in various disease and physiological states, Melatonin in the Promotion of Health, Second Edition provides a wide variety of expert reviews on the biology of melatonin relevant to health. Beginning with a history of melatonin and its relation to circadian rhythms, the book examines its use in a host of applications, including: Gut motility and gastrointestinal diseases Anesthesia and surgery Bone health Breast cancer Cardiovascular diseases Diabetes Age-related macular degeneration and uveitis Melanoma, solar skin damage, and collagen synthesis The prevention of DNA damage Mental disorders, sleep, and issues related to jet lag and shift work The data gathered from a large number of carefully controlled animal and human studies have clearly implicated melatonin in the control mechanisms of a wide variety of physiological and psychological activities, making it a potent candidate for therapeutic use in the treatment of a diverse range of diseases. This volume demonstrates that continued studies of this molecule raise the exciting prospect of providing new avenues of treating numerous diseases more effectively and with less side-effects than those found in conventional treatment modalities.

Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study.

With contributions from a cadre of international experts, this volume examines:

• The biology of DHEA relevant to health in humans
• Areas of potential clinical importance concerning low levels of DHEA related to age or physiological change
• Prevention as well as treatment of various human disease states by changing DHEA levels
• The use of DHEA levels in predicting the risk of disease
• The role of DHEA in diabetes, fitness, infectious disease, cancer, AIDS, bone health, cardiovascular diseases, autism, and mental health
• Animal models and their relation to studies done on humans
• The effects of loss of adrenal gland function, the subsequent reduction in DHEA production, and its replacement as therapy
• Adverse effects in DHEA-supplemented women
• Mechanisms of action of DHEA in prostate and ovarian health, vascular modification, stress, memory, aggression, and Alzheimer's disease

Covering a wide range of topics, the book is compiled from contributions of experts who have each studied some aspect of DHEA and human or animal health or disease. Every chapter is self-contained, allowing for focused study on individual topics. Edited by one of the leading experts in the field of nutrition, the book presents a compelling view of the state of the science in DHEA.

Distilling the available knowledge on ethanol-induced liver damage and directly complementing the available bio-medical literature, Ethanol and the Liver covers pathogenic and clinical aspects of alcoholic liver disease. Providing broader coverage of the subject than any available monograph, the editors and their panel of experts relate basic science to pathogenesis and treatment modalities and explore future developments. Coverage includes: Histopathology-fatty liver, alcoholic hepatitis, and cirrhosis Ethanol metabolism and its consequences Mechanisms in the pathogenesis of ALD, including genetics, immunology, and insulin-like growth factors Extrahepatic effects of ALD and the role of alcohol in potentiating liver damage due to other etiologies Interaction of alcohol with viral hepatitis Epidemiology, diagnosis, and treatment Management strategies, including transplantation The vast amount of knowledge and expertise gathered in this book make it an unparalleled resource.

Detailed Review of Nutritional Therapies Used to Combat Elderly Health Issues The combination of the aging baby-boomer generation and their increased longevity has been fortunately met with increased research and greater understanding of health promotion and disease prevention in the elderly. Handbook of Nutrition in the Aged: Fourth Edition shares these groundbreaking insights and serves as a guide to better understand health problems that occur in aging adults and the nutritional therapies that are proven to fight and prevent them. Addresses Requirements for Optimum Health of Aging Physiological Systems This sharply focused work recognizes the special nutrition hurdles associated with the aged, particularly the decline of nutrient intake that compromises health. As a globally relevant text, this fourth edition is extensively revised, updated, and expanded to reflect the latest research in nutrition and aging. New chapters to this edition include information on: Arthritis Cognition Nutrition and the geriatric surgery patient Nutrition supplementation in fracture care Coffee and hypertension Asian medicine This book is a valuable tool not only for geriatricians and gerontologists, but also for dieticians, nutritionists, and aging researchers. It provides all the necessary information for assisting the growing aging population in maintaining a healthy quality of life.

Over the past decade, much has been learned about the damaging effects of moderate to severe alcohol use has on tissue nutrient levels and dietary intake. Summarising current research, Nutrition and Alcohol explores the latest data available on the effects of alcohol on the nutritional state of alcohol abusers. It illustrates the combined effects of malnutrition on tissue damage and examines the role of altered nutrition on various alcohol-related diseases. The authors discuss alcohol's effects on nutrient intake and explain the action of nutrients in preventing and treating alcohol-related diseases.

As we age, our physiology changes. Also, we tend to place less emphasis on proper nutrition. The more elderly we grow, the less resistant we become to major diseases such as cancer and heart disease. This state of affairs renders the elderly more vulnerable to alcohol and other drugs of abuse. Alcohol and tobacco are routinely used together. Chronic exposure to these substances bring devastating consequences to bear on the elderly and often lead to their premature death.

Alcohol and Coffee Use in the Aging provides a detailed discussion of how alcohol affects the elderly, particularly in regard to the major health problems it causes. The book also examines the many physiological and cognitive changes that alcohol brings about. This book also addresses the role and effects of caffeine as a major factor contributing to insomnia in the elderly, as well as its association with hypertension and cancer.

Evidence shows that nutritional supports can help maintain health in the HIV-infected patient by replacing lost nutrients, compensating for nutritional damage done by the retrovirus-induced immunodeficiency, and stimulating the remaining immune system and cells for better host defenses.

This new edition of Nutrition and AIDS is a timely look at what dietary materials, supplements, and foods may benefit or treat AIDS, as well as nutritional deficiencies that can accelerate progression to AIDS and death. It offers a variety of alternative dietary and herbal remedies, including some that have been tested in animals and humans to stimulate immune defense or compensate for changes induced by HIV infection. In addition, it surveys items that may accelerate nutritional depletion in AIDS patients, such as cocaine, alcohol, and tobacco use. It includes data from animal studies modeling AIDS and nutrition, studies not yet done in humans but applicable to them.

Including updated reviews on topics from the author's earlier publications on the subject, with a focus on how to use this nutritional information to treat or retard development of AIDS, Nutrition and AIDS brings to the forefront the most recent advances in understanding the nutritional deficiencies of AIDS and HIV-positive patients.

The use of dietary vegetables and medicinal herbs to improve health is a phenomenon that is taking society by storm. Herbal products are now a multi-billion dollar business. Even more important, this business is built upon extremely little research data. The FDA is pushing the industry-with Congress' help- to base their claims and products on scientific phenomena.

Vegetables, Fruits, and Herbs in Health Promotion discusses the most effective ways of conducting research geared toward deriving maximum nutritional benefit from vegetables, fruits, and herbs. The book addresses such questions as:

o How much vegetables and herbs should be consumed?
o Can extracts or components be useful replacements for vegetable consumption?
o Does red wine reduce the risk of heart disease, and if so, what are the active agents and mechanisms?

Increased consumption of vegetables and herbs promotes health, increases longevity, and reduces the risk of cancer and heart disease. Vegetables, Fruits, and Herbs in Health Promotion is an invaluable reference for providing you with the knowledge necessary for fostering positive changes in dietary habits.

Well-illustrated throughout and with in-depth analyses, Nutrition, Diet Therapy, and the Liver provides a holistic understanding of the causative elements that precipitate liver disease and the nutritional factors and regimens that reverse deteriorating hepatic function. This up-to-date resource also incorporates emerging fields of science and significant discoveries. With contributions from leading experts of international repute in their respective fields, the book first emphasizes the important role nutrition plays not only in the prevention of liver disease but also in the reversal of liver dysfunction. The second section covers various aspects of alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) as well as the consequent steatohepatitis that encompasses the whole spectrum of triglyceride accumulation, inflammation, fibrosis, and end-stage cirrhosis of the liver. The book then focuses on the mounting evidence in support of alcohol abuse, hepatitis viruses, and immune diseases as key predisposing factors in the incidence of hepatocellular carcinomas. The final section evaluates the importance of nutrition in the treatment of liver diseases in infants versus adults, including recovery after liver transplantation.

Contents:
Part 1. Specific Lesions 1. Alcoholic Fatty Liver Andrew J. Bathgate and Kenneth J. Simpson 2. Alcoholic Hepatitus H. Denk, K. Zatloukal and C. StumptnerIN 3. Fibrosis in Alcoholic Cirrhosis Samuel W. French Part 2. Direct and Indirect Consequences of Alcohol Metabolism 4. Genetics of Ethanol Metabolism and Alcoholic Liver Disease Paul Y. Kwo and David W. Crabb 5. Acetaldehyde Adducts: Role in Ethanol-Induced Liver Disease John Koskinas Part 3. Mechanisms of Damage 6. Free Radicals and Alcohol-Induced Liver Injury Emanuele Albano 7. Ethanol and the Hepatic Microcirculation Robert S. McCuskey 8. Cytokines and Alcohol Liver Disease F. Javier Laso, J. Ignacio Madruga Alberto Orfao 9. Adhesion Molecules and Chemokines in Alcoholic Liver Disease Neil C. Fisher and David H. Adams 10. Role of Endotoxin and Kupffer Cells as Triggers of Hypoxia-Reoxygenation in Alcoholic Liver Injury R.G. Thurman, B.U. Bradford, K.T. Knecht, Y. Iimuro, G.E. Arteel, M. Yin, H.D. Connor, C. Rivera, J.A. Raleigh, M.V. Frankenberg, Y. Adachi, D.T. Forman, D. Brenner, M. Kadiiska and R.P. Mason 11. Ethanol and Protein Turnover Elena Volpi 12. Insulin-Like Growth Factors: Clinical and Experimental Anthony J. Donaghy 13. Cellular Mechanisms of Liver Regeneration and the Effect of Alcohol Martin Phillips, Elika Kashef and Robin Hughes 14. Alcohol and Hepatocellular Carcinoma Stephen D. Ryder 15. Animal Models of Ethanol-Induced Liver Disease Harri A. Järveläinen and Kai O. Lindros Part 4. Epidemiology and Diagnosis 16. Epidemiology and Comparative Incidence of Alcohol-Induced Liver Disease John B. Saunders and Benedict M. Devereaux 17. Serum Diagnosis of Alcoholic Liver Disease and Markers of Ethanol Intake Onni Niemelä Part 5. Extrahepatic Effects 18. Extrahepatic Effects of Alcohol: An Overview Helen L. Reeves and Christopher P. Day 19. Endocrine System Christian Gluud 20. Cardiomyopathy and Skeletal Muscle Myopathy Alvaro Urbano-Márquez, Joaquim Fernández-Solà and Ramon Estruch 21. Cerebral Consequences of Alcoholic Liver Disease Roger F. Butterworth Part 6. Management 22. General Management of Alcoholic Liver Disease Martin Phillips and John O'Grady 23. The Role of the Psychiatrist in the Treatment of Alcoholic Liver Disease José Martínez-Raga and E. Jane Marshall 24. Pharmacological Treatment for Alcoholic Hepatitis and Cirrhosis: Present Practice and Future Strategies Philippe Mathurin and Thierry Poynard 25. Nutritional Support in Alcoholic Liver Disease: Practical Management and Future Strategies Angela Madden 26. Alcohol and Viral Hepatitis: Interactions and Management Albert Parés and Joan Caballería 27. Liver Transplantation in Alcoholic Liver Disease Stephen P. Pereira and Roger Williams

Olives and Olive Oil in Health and Disease Prevention, Second Edition expands the last releases content and coverage, including new sections on materials in packaging, the Mediterranean diet, metabolic syndrome, diabetic health, generational effects, epigenetics, glycemic control, ketogenic diet, antioxidant effects, the use of olive oil in protection against skin cancer, oleuropein and ERK1/2 MAP-Kinase, oleocanthal and estrogen receptors, and oleocanthal and neurological effects. The book is a valuable resource for food and health researchers, nutritionists, dieticians, pharmacologists, public health scientists, epidemiologists, food technologists, agronomists, analytical chemists, biochemists, biologists, physicians, biotechnologists and students.

The Role of Functional Food Security in Global Health presents a collective approach to food security through the use of functional foods as a strategy to prevent under nutrition and related diseases. This approach reflects the views of the Food and Agriculture Organization of the United Nations, the World Health Organization, the World Heart Federation and the American Heart Association who advise Mediterranean, Paleolithic, plant food based diets, and European vegetarian diets for the prevention of cardiovascular disease. In addition, the book also emphasizes the inclusion of spices, herbs and millets, as well as animal foods. This book will be a great resource to the food industry as it presents the most efficient ways to use technology to manufacture slowly absorbed, micronutrient rich functional foods by blending foods that are rich in healthy nutrients.

Sleep disorder is a rampant problem in the US, with over 40 million Americans currently diagnosed according to the NIH. There is a clear association between sleep disorder and a wide range of other human disorders -performance deficiencies, psychiatric illnesses, heart disease, obesity and more - but in spite of this there is not yet a convenient overview on the market detailing the impact of obesity, age, diabetes and diet on sleep duration and attendant health outcomes. This volume focuses on the interaction between sleep and these factors, with special attention being paid to the potential for neurological modulation of sleep via diet. The volume aid readers in understanding the role each of these factors plays in sleep architecture and its regulation by circadian biology and neurology.

Nutritional Modulators of Pain in the Aging Population provides an overview on the role of foods, dietary supplements, obesity, and nutrients in the prevention and amelioration of pain in various diseases in the aging population. Headaches, fibromyalgia, joint pain, arthritis pain, back pain, and stomach pain are discussed. In addition, the potential health risks of using foods to reduce symptoms is evaluated. Each chapter reviews pain causing conditions before reviewing the role of food or exercise. Both researchers and physicians will learn about dietary approaches that may benefit or harm people with various types of pain. Chapters include current research on the actions of nutrients in pain treatment, the effects of lifestyle and exercise on pain management, and discussions of dietary supplements that provide pain relief from chronic conditions like arthritis.

Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual's lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances.

Bioactive Foods in Promoting Health: Probiotics and Prebiotics brings together experts working on the different aspects of supplementation, foods, and bacterial preparations, in health promotion and disease prevention, to provide current scientific information, as well as providing a framework upon which to build clinical disease treatment studies. Since common dietary bacterial preparations are over-the-counter and readily available, this book will be useful to the growing nutrition, food science, and natural product community that will use it as a resource in identifying dietary behavioral modifications in pursuit of improved health as well as for treatment of specific disease, as it focuses on the growing body of knowledge of the role of various bacteria in reducing disease risk and disease. Probiotics are now a multi-billion-dollar, dietary supplement business which is built upon extremely little research data. In order to follow the 1994 ruling, the U.S. Food and Drug Administration with the support of Congress is currently pushing this industry to base its claims and products on scientific research. Research as shown that dietary habits need to be altered for most people whether for continued or improved good health. The conclusions and recommendations from the various chapters in this book will provide a basis for those important factors of change by industry with new uses. Animal studies and early clinical ones will lead to new uses and studies. Particularly the cutting edge experimental and clinical studies from Europe will provide novel approaches to clinical uses through their innovative new studies.

Fruits, Vegetables, and Herbs: Bioactive Foods in Health Promotion brings together experts from around the world working on the cutting edge of research on fruit, vegetables, and herbs in health promotion. Offering a timely, concise, scientific appraisal of the efficacy of key foods to prevent disease and improve the quality of life, Fruits, Vegetables, and Herbs: Bioactive Foods in Health Promotion provides valuable evidence-based conclusions and recommendations. This reference text will encourage further research on the potential benefits of fruits and vegetables in health and disease prevention, providing a basis for possible dietary modifications by the government and the public.

Genetically Modified Organisms in Food focuses on scientific evaluation of published research relating to GMO food products to assert their safety as well as potential health risks. This book is a solid reference for researchers and professionals needing information on the safety of GMO and non-GMO food production, the economic benefits of both GMO and non-GMO foods, and includes in-depth coverage of the surrounding issues of genetic engineering in foods. This is a timely publication written by a team of scientific experts in the field who present research results to help further more evidence based research to educate scientists, academics, government professionals about the safety of the global food supply.

Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men.

One major example of the synergy of bioactive foods and extracts is their role as an antioxidant and the related remediation of cardiovascular disease. There is compelling evidence tosuggest that oxidative stress is implicated in the physiology of several major cardiovascular diseases including heart failure and increased free radical formation and reduced antioxidant defences. Studies indicate bioactive foods reduce the incidence of these conditions, suggestive of a potential cardioprotective role of antioxidant nutrients.

BioactiveFood as Dietary Interventions for Cardiovascular Diseaseinvestigates the role of foods, herbs and novel extracts in moderating the pathology leading to cardiovascular disease. It reviews existing literature, and presents new hypotheses and conclusions on the effects of different bioactive components of the diet.
Addresses the most positive results from dietary interventions using bioactive foods to impact cardiovascular diseaseDocuments foods that can affect metabolic syndrome and other related conditionsConvenient, efficient and effective source that allows readers to identify potential uses of compounds or indicate those compounds whose use may be of little or no health benefitAssociated information can be used to understand other diseases that share common etiological pathways"

The first 90 years of vitamin E research has produced prolific and notable discoveries, but until the last few decades, attention has been given mostly to the biological activities and underlying mechanisms of alpha-tocopherol, which we now know is one of more than eight vitamin E isomers. Currently, the non-tocopherol vitamin E molecule tocotrienol has reached a new measure of research height: more than one-third of all vitamin E tocotrienol research of the last 30 years has been published since 2009. The thriving field of tocotrienol research gives ground for publication of Tocotrienols: Vitamin E Beyond Tocopherols, Second Edition, a compilation of the latest tocotrienol research in all new chapters. Highlights Established research, including prevention and treatment of cardiovascular disease, metabolic syndrome, and cancer Emergent research, including angiogenesis, bioavailability, bone health, gastric injury, inflammation, life extension, and skin health Tocopherol interference with tocotrienol functions All new chapters and many new contributors Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis, and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book overviews tocotrienols, and examines their sources, chemistry, and mechanisms of action. Contributors discuss the role of tocotrienols in the treatment and prevention of cancer and in cardiovascular health, diabetes, and other hormone regulation by tocotrienols. In addition, the book addresses animal and in vitro as well as mechanistic and pre-clinical studies. Dr. Tan discusses the benefits of tocotrienol in a YouTube video.